7ZV3

Crystal structure of indoleamine 2,3-dioxygenase 1 (IDO1) in complex with ferric heme and MMG-0472

7ZV3 の概要

• エントリーDOI: 10.2210/pdb7zv3/pdb
• 分子名称: Indoleamine 2,3-dioxygenase 1, PROTOPORPHYRIN IX CONTAINING FE, 4-(3-chloro-2-phenethylphenyl)-1H-1,2,3-triazole, ... (6 entities in total)
• 機能のキーワード: dioxygenase, heme-containing enzyme, structure-based drug design, triazole, small-molecule inhibitor, oxidoreductase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 97093.70

構造登録者

Roehrig, U.F.,Reynaud, A.,Pojer, F.,Michielin, O.,Zoete, V. (登録日: 2022-05-13, 公開日: 2022-07-06, 最終更新日: 2024-03-27)

• 主引用文献: Rohrig, U.F.,Majjigapu, S.R.,Vogel, P.,Reynaud, A.,Pojer, F.,Dilek, N.,Reichenbach, P.,Ascencao, K.,Irving, M.,Coukos, G.,Michielin, O.,Zoete, V.; Structure-based optimization of type III indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors.; J Enzyme Inhib Med Chem, 37:1773-1811, 2022; PubMed: 35758198; DOI: 10.1080/14756366.2022.2089665

実験手法

X-RAY DIFFRACTION (2.551 Å)