7ZU8

Crystal Structure of the zymogen form of the glutamic-class prolyl-endopeptidase neprosin at 2.05 A resolution in presence of the crystallophore Lu-Xo4.

7ZU8 の概要

• エントリーDOI: 10.2210/pdb7zu8/pdb
• 分子名称: Glutamyl endopeptidase Neprosin, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• 機能のキーワード: glutamic endopeptidase, zymogen, proform, coeliac disease therapy, crystallophore, hydrolase
• 由来する生物種: Nepenthes ventricosa x Nepenthes alata
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 45266.54

構造登録者

Del Amo-Maestro, L.,Eckhard, U.,Rodriguez-Banqueri, A.,Mendes, S.R.,Guevara, T.,Gomis-Ruth, F.X. (登録日: 2022-05-11, 公開日: 2022-08-10)

• 主引用文献: Del Amo-Maestro, L.,Mendes, S.R.,Rodriguez-Banqueri, A.,Garzon-Flores, L.,Girbal, M.,Rodriguez-Lagunas, M.J.,Guevara, T.,Franch, A.,Perez-Cano, F.J.,Eckhard, U.,Gomis-Ruth, F.X.; Molecular and in vivo studies of a glutamate-class prolyl-endopeptidase for coeliac disease therapy.; Nat Commun, 13:4446-4446, 2022; PubMed: 35915115; DOI: 10.1038/s41467-022-32215-1

実験手法

X-RAY DIFFRACTION (2.05 Å)