7ZQS

Cryo-EM Structure of Human Transferrin Receptor 1 bound to DNA Aptamer

Summary for 7ZQS

Entry DOI	10.2210/pdb7zqs/pdb
EMDB information	14874
Descriptor	DNA (30-MER), Transferrin receptor protein 1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
Functional Keywords	cd71, transmembrane glycoprotein, membrane protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	204147.74
Authors	Bansia, H.,Wang, T.,Gutierrez, D.,des Georges, A. (deposition date: 2022-05-02, release date: 2022-08-17)
Primary citation	Cheng, E.L.,Cardle, I.I.,Kacherovsky, N.,Bansia, H.,Wang, T.,Zhou, Y.,Raman, J.,Yen, A.,Gutierrez, D.,Salipante, S.J.,des Georges, A.,Jensen, M.C.,Pun, S.H. Discovery of a Transferrin Receptor 1-Binding Aptamer and Its Application in Cancer Cell Depletion for Adoptive T-Cell Therapy Manufacturing. J.Am.Chem.Soc., 144:13851-13864, 2022 Cited by PubMed: 35875870 DOI: 10.1021/jacs.2c05349 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.54 Å)

Structure validation