7ZQS

Cryo-EM Structure of Human Transferrin Receptor 1 bound to DNA Aptamer

7ZQS の概要

• エントリーDOI: 10.2210/pdb7zqs/pdb
• EMDBエントリー: 14874
• 分子名称: DNA (30-MER), Transferrin receptor protein 1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• 機能のキーワード: cd71, transmembrane glycoprotein, membrane protein
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 204147.74

構造登録者

Bansia, H.,Wang, T.,Gutierrez, D.,des Georges, A. (登録日: 2022-05-02, 公開日: 2022-08-17)

• 主引用文献: Cheng, E.L.,Cardle, I.I.,Kacherovsky, N.,Bansia, H.,Wang, T.,Zhou, Y.,Raman, J.,Yen, A.,Gutierrez, D.,Salipante, S.J.,des Georges, A.,Jensen, M.C.,Pun, S.H.; Discovery of a Transferrin Receptor 1-Binding Aptamer and Its Application in Cancer Cell Depletion for Adoptive T-Cell Therapy Manufacturing.; J.Am.Chem.Soc., 144:13851-13864, 2022; PubMed: 35875870; DOI: 10.1021/jacs.2c05349

実験手法

ELECTRON MICROSCOPY (2.54 Å)