7ZMS

Crystal structure of human RECQL5 helicase APO form in complex with engineered nanobody (Gluebody) G4-043

Summary for 7ZMS

• Entry DOI: 10.2210/pdb7zms/pdb
• Descriptor: ATP-dependent DNA helicase Q5, Gluebody G4-043, ZINC ION, ... (4 entities in total)
• Functional Keywords: helicase, apo form, nanobody complex, hydrolase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 63221.67

Authors

Ye, M.,Makola, M.,Newman, J.A.,Fairhead, M.,MacLean, E.,Krojer, T.,Aitkenhead, H.,Bountra, C.,Gileadi, O.,von Delft, F. (deposition date: 2022-04-19, release date: 2022-07-13, Last modification date: 2024-01-31)

• Primary citation: Ye, M.,Makola, M.,Newman, J.A.,Fairhead, M.,MacLean, E.,Krojer, T.,Wright, N.D.,Koekemoer, L.,Thompson, A.,Bezerra, G.A.,Yi, G.,Li, H.,Rangel, V.L.,Mamalis, D.,Aitkenhead, H.,Gilbert, R.J.C.,Duerr, K.,Davis, B.G.,Bountra, C.,Gileadi, O.,von Delft, F.; Gluebodies improve crystal reliability and diversity through transferable nanobody mutations that introduce constitutive crystal contacts; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.7 Å)