7ZMI

Crystal Structure of Unlinked NS2B_NS3 Protease from Zika Virus in Complex with Inhibitor MI-2113

7ZMI の概要

• エントリーDOI: 10.2210/pdb7zmi/pdb
• 分子名称: Serine protease subunit NS2B, Serine protease NS3, (2~{R})-6-[[(2~{S})-6-azanyl-2-[[(2~{S})-6-azanyl-2-(2-phenylethanoylamino)hexanoyl]amino]hexanoyl]amino]-2-carbamimidamido-hexanoic acid, ... (4 entities in total)
• 機能のキーワード: flavivirin, serine protease, viral protein, ns2b-ns3, zika virus
• 由来する生物種: Zika virus; 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 25465.68

構造登録者

Huber, S.,Steinmetzer, T. (登録日: 2022-04-19, 公開日: 2022-12-28, 最終更新日: 2024-02-07)

• 主引用文献: Hammerschmidt, S.J.,Huber, S.,Braun, N.J.,Lander, M.,Steinmetzer, T.,Kersten, C.; Thermodynamic characterization of a macrocyclic Zika virus NS2B/NS3 protease inhibitor and its acyclic analogs.; Arch Pharm, 356:e2200518-e2200518, 2023; PubMed: 36480352; DOI: 10.1002/ardp.202200518

実験手法

X-RAY DIFFRACTION (2.15 Å)