7ZJF

R399E, a mutated form of GDF5, for disease modification of osteoarthritis

Summary for 7ZJF

Entry DOI	10.2210/pdb7zjf/pdb
Descriptor	Growth/differentiation factor 5 (2 entities in total)
Functional Keywords	growth factor, growth differentiation factor, bone morphogenetic, signaling protein
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	27141.12
Authors	Gigout, A.,Wekmann, D.,Menges, S.,Brenneis, C.,Henson, F.,Cowan, K.J.,Musil, D.,Thudium, C.,Guehring, H.,Michaelis, M.,Kleinschmidt-Doerr, K. (deposition date: 2022-04-10, release date: 2022-09-28, Last modification date: 2024-11-06)
Primary citation	Gigout, A.,Werkmann, D.,Menges, S.,Brenneis, C.,Henson, F.,Cowan, K.J.,Musil, D.,Thudium, C.S.,Guhring, H.,Michaelis, M.,Kleinschmidt-Doerr, K. R399E, A Mutated Form of Growth and Differentiation Factor 5, for Disease Modification of Osteoarthritis. Arthritis Rheumatol, 75:375-386, 2023 Cited by PubMed Abstract: To preclinically characterize a mutant form of growth and differentiation factor 5, R399E, with reduced osteogenic properties as a potential disease-modifying osteoarthritis (OA) drug. PubMed: 36054172 DOI: 10.1002/art.42343 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.3 Å)

Structure validation