7ZEG

Human cytosolic 5' nucleotidase IIIB in complex with 3,4-diF-Bn7GMP

7ZEG の概要

• エントリーDOI: 10.2210/pdb7zeg/pdb
• 分子名称: 7-methylguanosine phosphate-specific 5'-nucleotidase, N7-(3,4-difluorobenzyl) guanosine 5'-monophosphate, 1,2-ETHANEDIOL, ... (5 entities in total)
• 機能のキーワード: cytosolic 5' nucleotidase, n7 methylguanosine monophosphate dephosphorylation, mrna cap degradation, hydrolase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 70690.98

構造登録者

Kubacka, D.,Kozarski, M.,Baranowski, M.R.,Wojcik, R.,Jemielity, J.,Kowalska, J.,Basquin, J. (登録日: 2022-03-31, 公開日: 2022-04-13, 最終更新日: 2024-01-31)

• 主引用文献: Kubacka, D.,Kozarski, M.,Baranowski, M.R.,Wojcik, R.,Panecka-Hofman, J.,Strzelecka, D.,Basquin, J.,Jemielity, J.,Kowalska, J.; Substrate-Based Design of Cytosolic Nucleotidase IIIB Inhibitors and Structural Insights into Inhibition Mechanism.; Pharmaceuticals, 15:-, 2022; PubMed: 35631380; DOI: 10.3390/ph15050554

実験手法

X-RAY DIFFRACTION (1.56 Å)