7Z6I
Crystal structure of p38alpha C162S in complex with SB20358 and CAS 2094667-81-7 (behind catalytic site; Y35 in), P 21 21 21
This is a non-PDB format compatible entry.
Summary for 7Z6I
Entry DOI | 10.2210/pdb7z6i/pdb |
Related | 7PV3 7PVU 7Q1A |
Descriptor | Mitogen-activated protein kinase 14, 4-[4-(4-fluorophenyl)-2-[4-[methyl(oxidanyl)-$l^{3}-sulfanyl]phenyl]-1~{H}-imidazol-5-yl]pyridine, N-(2-cyclobutyl-1H-1,3-benzodiazol-5-yl)benzenesulfonamide, ... (4 entities in total) |
Functional Keywords | kinase, enzyme, inhibitor, ligand, oncoprotein |
Biological source | Mus musculus (house mouse) |
Total number of polymer chains | 1 |
Total formula weight | 42067.98 |
Authors | Baginski, B.,Pous, J.,Gonzalez, L.,Macias, M.J.,Nebreda, A.R. (deposition date: 2022-03-11, release date: 2023-06-14, Last modification date: 2024-02-07) |
Primary citation | Gonzalez, L.,Diaz, L.,Pous, J.,Baginski, B.,Duran-Corbera, A.,Scarpa, M.,Brun-Heath, I.,Igea, A.,Martin-Malpartida, P.,Ruiz, L.,Pallara, C.,Esguerra, M.,Colizzi, F.,Mayor-Ruiz, C.,Biondi, R.M.,Soliva, R.,Macias, M.J.,Orozco, M.,Nebreda, A.R. Characterization of p38 alpha autophosphorylation inhibitors that target the non-canonical activation pathway. Nat Commun, 14:3318-3318, 2023 Cited by PubMed: 37308482DOI: 10.1038/s41467-023-39051-x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
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