7Z6C

Crystal structure of human Dihydroorotate Dehydrogenase in complex with the inhibitor 2-Hydroxy-N-(2-ispropyl-5-methyl-4-phenoxyphenyl)pyrazolo[1,5-a]pyridine-3-carboxamide.

7Z6C の概要

• エントリーDOI: 10.2210/pdb7z6c/pdb
• 分子名称: Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, OROTIC ACID, ... (7 entities in total)
• 機能のキーワード: dihydroorotate dehydrogenase, inhibitor, complex, acute myeloid leukaemia., oxidoreductase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 41080.62

構造登録者

Alberti, M.,Lolli, M.L.,Boschi, D.,Sainas, S.,Rizzi, M.,Ferraris, D.M.,Miggiano, R. (登録日: 2022-03-11, 公開日: 2022-10-12, 最終更新日: 2024-01-31)

• 主引用文献: Sainas, S.,Giorgis, M.,Circosta, P.,Poli, G.,Alberti, M.,Passoni, A.,Gaidano, V.,Pippione, A.C.,Vitale, N.,Bonanni, D.,Rolando, B.,Cignetti, A.,Ramondetti, C.,Lanno, A.,Ferraris, D.M.,Canepa, B.,Buccinna, B.,Piccinini, M.,Rizzi, M.,Saglio, G.,Al-Karadaghi, S.,Boschi, D.,Miggiano, R.,Tuccinardi, T.,Lolli, M.L.; Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5- a ]pyridine Scaffold: SAR of the Aryloxyaryl Moiety.; J.Med.Chem., 65:12701-12724, 2022; PubMed: 36162075; DOI: 10.1021/acs.jmedchem.2c00496

実験手法

X-RAY DIFFRACTION (1.85 Å)