7Z5W

ROS1 with AstraZeneca ligand 1

7Z5W の概要

• エントリーDOI: 10.2210/pdb7z5w/pdb
• 分子名称: Proto-oncogene tyrosine-protein kinase ROS, ~{N}-[6-methyl-2-[(2~{S})-2-[3-(3-methylpyrazin-2-yl)-1,2-oxazol-5-yl]pyrrolidin-1-yl]pyrimidin-4-yl]-1,3-thiazol-2-amine, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: virtual screening, potent selective, ros1, kinase inhibitors, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 76335.01

構造登録者

Hargreaves, D. (登録日: 2022-03-10, 公開日: 2022-08-17, 最終更新日: 2024-01-31)

• 主引用文献: Petrovic, D.,Scott, J.S.,Bodnarchuk, M.S.,Lorthioir, O.,Boyd, S.,Hughes, G.M.,Lane, J.,Wu, A.,Hargreaves, D.,Robinson, J.,Sadowski, J.; Virtual Screening in the Cloud Identifies Potent and Selective ROS1 Kinase Inhibitors.; J.Chem.Inf.Model., 62:3832-3843, 2022; PubMed: 35920716; DOI: 10.1021/acs.jcim.2c00644

実験手法

X-RAY DIFFRACTION (2.254 Å)