7Z5U

Crystal structure of the peptidase domain of collagenase G from Clostridium histolyticum in complex with a hydroxamate-based inhibitor

Summary for 7Z5U

Entry DOI	10.2210/pdb7z5u/pdb
Related	2y6i
Descriptor	Collagenase ColG, ZINC ION, (2~{R})-~{N}-[2-[4-[(2-acetamidophenoxy)methyl]-1,2,3-triazol-1-yl]ethyl]-2-(2-methylpropyl)-~{N}'-oxidanyl-propanediamide, ... (5 entities in total)
Functional Keywords	collagenase, hydroxamate, colg, inhibitor, complex, hydrolase
Biological source	Hathewaya histolytica
Total number of polymer chains	1
Total formula weight	48423.84
Authors	Schoenauer, E.,Brandstetter, H. (deposition date: 2022-03-10, release date: 2022-11-09, Last modification date: 2024-01-31)
Primary citation	Alhayek, A.,Abdelsamie, A.S.,Schonauer, E.,Camberlein, V.,Hutterer, E.,Posselt, G.,Serwanja, J.,Blochl, C.,Huber, C.G.,Haupenthal, J.,Brandstetter, H.,Wessler, S.,Hirsch, A.K.H. Discovery and Characterization of Synthesized and FDA-Approved Inhibitors of Clostridial and Bacillary Collagenases. J.Med.Chem., 65:12933-12955, 2022 Cited by PubMed: 36154055 DOI: 10.1021/acs.jmedchem.2c00785 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation