7Z5U

Crystal structure of the peptidase domain of collagenase G from Clostridium histolyticum in complex with a hydroxamate-based inhibitor

7Z5U の概要

• エントリーDOI: 10.2210/pdb7z5u/pdb
• 関連するPDBエントリー: 2y6i
• 分子名称: Collagenase ColG, ZINC ION, (2~{R})-~{N}-[2-[4-[(2-acetamidophenoxy)methyl]-1,2,3-triazol-1-yl]ethyl]-2-(2-methylpropyl)-~{N}'-oxidanyl-propanediamide, ... (5 entities in total)
• 機能のキーワード: collagenase, hydroxamate, colg, inhibitor, complex, hydrolase
• 由来する生物種: Hathewaya histolytica
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 48423.84

構造登録者

Schoenauer, E.,Brandstetter, H. (登録日: 2022-03-10, 公開日: 2022-11-09, 最終更新日: 2024-01-31)

• 主引用文献: Alhayek, A.,Abdelsamie, A.S.,Schonauer, E.,Camberlein, V.,Hutterer, E.,Posselt, G.,Serwanja, J.,Blochl, C.,Huber, C.G.,Haupenthal, J.,Brandstetter, H.,Wessler, S.,Hirsch, A.K.H.; Discovery and Characterization of Synthesized and FDA-Approved Inhibitors of Clostridial and Bacillary Collagenases.; J.Med.Chem., 65:12933-12955, 2022; PubMed: 36154055; DOI: 10.1021/acs.jmedchem.2c00785

実験手法

X-RAY DIFFRACTION (1.8 Å)