7Z4V

Structure of Serine-Threonine kinase STK25 in complex with compound

7Z4V の概要

• エントリーDOI: 10.2210/pdb7z4v/pdb
• 分子名称: Serine/threonine-protein kinase 25, ~{N}-(5-~{tert}-butyl-1~{H}-pyrazol-3-yl)-4-pyrrolidin-1-ylsulfonyl-benzamide, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: tumor suppressor, phosphorylation, yap/taz, kinase, oncoprotein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34356.28

構造登録者

Nawrotek, A.,Vuillard, L.,Miallau, L. (登録日: 2022-03-04, 公開日: 2022-04-06, 最終更新日: 2024-01-31)

• 主引用文献: Kiyeleko, S.,Hocine, S.,Mautino, G.,Kuenemann, M.,Nawrotek, A.,Miallau, L.,Vuillard, L.M.,Mirguet, O.,Kotschy, A.,Hanessian, S.; Targeting non-alcoholic fatty liver disease: Design, X-ray co-crystal structure and synthesis of 'first-in-kind' inhibitors of serine/threonine kinase25.; Bioorg.Med.Chem.Lett., 75:128950-128950, 2022; PubMed: 36030002; DOI: 10.1016/j.bmcl.2022.128950

実験手法

X-RAY DIFFRACTION (1.644 Å)