7Z3Q

Crystal structure of the human leptin:LepR-CRH2 encounter complex to 3.6 A resolution.

Summary for 7Z3Q

• Entry DOI: 10.2210/pdb7z3q/pdb
• Descriptor: Leptin, Leptin receptor (3 entities in total)
• Functional Keywords: leptin, obesity, leptin receptor, lepr, adipose tissue, hypothalamus, immune system, cytokine
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 134165.08

Authors

Verstraete, K.,Verschueren, K.,Alexandra, T.,Savvides, S.N. (deposition date: 2022-03-02, release date: 2023-03-22, Last modification date: 2024-02-07)

• Primary citation: Tsirigotaki, A.,Dansercoer, A.,Verschueren, K.H.G.,Markovic, I.,Pollmann, C.,Hafer, M.,Felix, J.,Birck, C.,Van Putte, W.,Catteeuw, D.,Tavernier, J.,Fernando Bazan, J.,Piehler, J.,Savvides, S.N.,Verstraete, K.; Mechanism of receptor assembly via the pleiotropic adipokine Leptin.; Nat.Struct.Mol.Biol., 30:551-563, 2023; PubMed: 36959263; DOI: 10.1038/s41594-023-00941-9

Experimental method

X-RAY DIFFRACTION (3.617 Å)