7Z3L

Autotaxin in complex with hybrid compound ziritaxestat (GLPG1690)

これはPDB形式変換不可エントリーです。

7Z3L の概要

• エントリーDOI: 10.2210/pdb7z3l/pdb
• 分子名称: Isoform 2 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, 2-[[2-ethyl-8-methyl-6-[4-[2-(3-oxidanylazetidin-1-yl)-2-oxidanylidene-ethyl]piperazin-1-yl]imidazo[1,2-a]pyridin-3-yl]-methyl-amino]-4-(4-fluorophenyl)-1,3-thiazole-5-carbonitrile, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose, ... (11 entities in total)
• 機能のキーワード: enpp2, lysophosphatidic acid, lipid chaperone, ; pulmonary fibrosis, gpcr, drug development, small-molecule inhibitor, hydrolase
• 由来する生物種: Rattus norvegicus (Norway rat)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 97312.47

構造登録者

Salgado-Polo, F.,Ford, P.,Heckmann, B.,Perrakis, A. (登録日: 2022-03-02, 公開日: 2023-01-25, 最終更新日: 2024-02-07)

• 主引用文献: Salgado-Polo, F.,Borza, R.,Matsoukas, M.T.,Marsais, F.,Jagerschmidt, C.,Waeckel, L.,Moolenaar, W.H.,Ford, P.,Heckmann, B.,Perrakis, A.; Autotaxin facilitates selective LPA receptor signaling.; Cell Chem Biol, 30:69-84.e14, 2023; PubMed: 36640760; DOI: 10.1016/j.chembiol.2022.12.006

実験手法

X-RAY DIFFRACTION (2.4 Å)