7Z28

High-resolution crystal structure of ERAP1 with bound bestatin analogue inhibitor

Summary for 7Z28

Entry DOI	10.2210/pdb7z28/pdb
Descriptor	Endoplasmic reticulum aminopeptidase 1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
Functional Keywords	erap1, aminopeptidase, zinc, metallopeptidase, bestatin, bestatin analogue, inhibitor, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	100985.39
Authors	Giastas, P.,Papakyriakou, A.,Stratikos, E.,Vourloumis, D. (deposition date: 2022-02-26, release date: 2022-07-27, Last modification date: 2024-01-31)
Primary citation	Vourloumis, D.,Mavridis, I.,Athanasoulis, A.,Temponeras, I.,Koumantou, D.,Giastas, P.,Mpakali, A.,Magrioti, V.,Leib, J.,van Endert, P.,Stratikos, E.,Papakyriakou, A. Discovery of Selective Nanomolar Inhibitors for Insulin-Regulated Aminopeptidase Based on alpha-Hydroxy-beta-amino Acid Derivatives of Bestatin. J.Med.Chem., 65:10098-10117, 2022 Cited by PubMed: 35833347 DOI: 10.1021/acs.jmedchem.2c00904 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.55 Å)

Structure validation