7Z28

High-resolution crystal structure of ERAP1 with bound bestatin analogue inhibitor

7Z28 の概要

• エントリーDOI: 10.2210/pdb7z28/pdb
• 分子名称: Endoplasmic reticulum aminopeptidase 1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
• 機能のキーワード: erap1, aminopeptidase, zinc, metallopeptidase, bestatin, bestatin analogue, inhibitor, hydrolase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 100985.39

構造登録者

Giastas, P.,Papakyriakou, A.,Stratikos, E.,Vourloumis, D. (登録日: 2022-02-26, 公開日: 2022-07-27, 最終更新日: 2024-01-31)

• 主引用文献: Vourloumis, D.,Mavridis, I.,Athanasoulis, A.,Temponeras, I.,Koumantou, D.,Giastas, P.,Mpakali, A.,Magrioti, V.,Leib, J.,van Endert, P.,Stratikos, E.,Papakyriakou, A.; Discovery of Selective Nanomolar Inhibitors for Insulin-Regulated Aminopeptidase Based on alpha-Hydroxy-beta-amino Acid Derivatives of Bestatin.; J.Med.Chem., 65:10098-10117, 2022; PubMed: 35833347; DOI: 10.1021/acs.jmedchem.2c00904

実験手法

X-RAY DIFFRACTION (1.55 Å)