7Z01

Z-SBTubA4 photoswitch bound to tubulin-DARPin D1 complex

7Z01 の概要

• エントリーDOI: 10.2210/pdb7z01/pdb
• 分子名称: Tubulin alpha-1B chain, Tubulin beta-2B chain, Designed Ankyrin Repeat Protein (DARPIN) D1, ... (9 entities in total)
• 機能のキーワード: microtubule dynamics; cytoskeleton; photopharmacology; tubulin polymerisation inhibitor; optical control; colchicine; antimitotic; cell division; cell migration; development; photoswitch, cell cycle
• 由来する生物種: synthetic construct; 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 119678.97

構造登録者

Wranik, M.,Weinert, T.,Standfuss, J.,Steinmetz, M. (登録日: 2022-02-21, 公開日: 2022-03-30, 最終更新日: 2024-01-31)

• 主引用文献: Gao, L.,Meiring, J.C.M.,Varady, A.,Ruider, I.E.,Heise, C.,Wranik, M.,Velasco, C.D.,Taylor, J.A.,Terni, B.,Weinert, T.,Standfuss, J.,Cabernard, C.C.,Llobet, A.,Steinmetz, M.O.,Bausch, A.R.,Distel, M.,Thorn-Seshold, J.,Akhmanova, A.,Thorn-Seshold, O.; In Vivo Photocontrol of Microtubule Dynamics and Integrity, Migration and Mitosis, by the Potent GFP-Imaging-Compatible Photoswitchable Reagents SBTubA4P and SBTub2M.; J.Am.Chem.Soc., 144:5614-5628, 2022; PubMed: 35290733; DOI: 10.1021/jacs.2c01020

実験手法

X-RAY DIFFRACTION (1.82 Å)