7YZH

Schistosoma Mansoni Carbonic Anhydrase in complex with 4-oxo-N-(4-sulfamoylphenethyl)-1,3,4,6,7,11b-hexahydro-2H-pyrazino[2,1-a]isoquinoline-2-carbothioamide

This is a non-PDB format compatible entry.

Summary for 7YZH

• Entry DOI: 10.2210/pdb7yzh/pdb
• Descriptor: Carbonic anhydrase, ZINC ION, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• Functional Keywords: schistosoma mansoni, carbonic anhydrase, sulfonamide, , metalloenzyme, lyase
• Biological source: Schistosoma mansoni
• Total number of polymer chains: 2
• Total formula weight: 76194.16

Authors

Angeli, A.,Ferraroni, M. (deposition date: 2022-02-20, release date: 2023-03-01, Last modification date: 2024-02-07)

• Primary citation: Angeli, A.,Ferraroni, M.,Carta, F.,Haberli, C.,Keiser, J.,Costantino, G.,Supuran, C.T.; Development of Praziquantel sulphonamide derivatives as antischistosomal drugs.; J Enzyme Inhib Med Chem, 37:1479-1494, 2022; PubMed: 35635137; DOI: 10.1080/14756366.2022.2078970

Experimental method

X-RAY DIFFRACTION (1.79 Å)