7YTV

Crystal structure of Aspergillus fumigatus Thioredoxin reductase in complex with auranofin

Summary for 7YTV

• Entry DOI: 10.2210/pdb7ytv/pdb
• Descriptor: Thioredoxin reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, FLAVIN-ADENINE DINUCLEOTIDE, ... (4 entities in total)
• Functional Keywords: thioredoxin reductase, reductase, auranofin, oxidoreductase
• Biological source: Aspergillus fumigatus
• Total number of polymer chains: 2
• Total formula weight: 82781.93

Authors

Lin, W. (deposition date: 2022-08-16, release date: 2023-06-28, Last modification date: 2023-11-29)

Primary citation

Chen, P.,Yang, J.,Jin, Y.,Lu, C.,Feng, Z.,Gao, F.,Chen, Y.,Wang, F.,Shang, Z.,Lin, W.
In vitro antifungal and antibiofilm activities of auranofin against itraconazole-resistant Aspergillus fumigatus.
J Mycol Med, 33:101381-101381, 2023

PubMed Abstract: Infections caused by azole-resistant Aspergillus are a rising public health threat with high mortality rates, high treatment costs and limited available antifungals, indicating an urgent need for new antifungals or strategies. Our aim was to investigate antifungal and antibiofilm activities of auranofin, an FDA-approved anti-antirheumatic drug.

PubMed: 37037064
DOI: 10.1016/j.mycmed.2023.101381

Experimental method

X-RAY DIFFRACTION (3.866 Å)