7YTV

Crystal structure of Aspergillus fumigatus Thioredoxin reductase in complex with auranofin

7YTV の概要

• エントリーDOI: 10.2210/pdb7ytv/pdb
• 分子名称: Thioredoxin reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, FLAVIN-ADENINE DINUCLEOTIDE, ... (4 entities in total)
• 機能のキーワード: thioredoxin reductase, reductase, auranofin, oxidoreductase
• 由来する生物種: Aspergillus fumigatus
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 82781.93

構造登録者

Lin, W. (登録日: 2022-08-16, 公開日: 2023-06-28, 最終更新日: 2023-11-29)

主引用文献

Chen, P.,Yang, J.,Jin, Y.,Lu, C.,Feng, Z.,Gao, F.,Chen, Y.,Wang, F.,Shang, Z.,Lin, W.
In vitro antifungal and antibiofilm activities of auranofin against itraconazole-resistant Aspergillus fumigatus.
J Mycol Med, 33:101381-101381, 2023

PubMed Abstract: Infections caused by azole-resistant Aspergillus are a rising public health threat with high mortality rates, high treatment costs and limited available antifungals, indicating an urgent need for new antifungals or strategies. Our aim was to investigate antifungal and antibiofilm activities of auranofin, an FDA-approved anti-antirheumatic drug.

PubMed: 37037064
DOI: 10.1016/j.mycmed.2023.101381

実験手法

X-RAY DIFFRACTION (3.866 Å)