7YQ5

human insulin receptor bound with A62 DNA aptamer and insulin

Summary for 7YQ5

Entry DOI	10.2210/pdb7yq5/pdb
EMDB information	34020
Descriptor	Insulin A chain, Insulin, isoform 2, IR-A62 aptamer, ... (4 entities in total)
Functional Keywords	receptor-ligand complex_b_overall, structural protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	5
Total formula weight	221017.90
Authors	Kim, J.,Yunn, N.,Ryu, S.,Cho, Y. (deposition date: 2022-08-05, release date: 2022-11-09, Last modification date: 2024-05-08)
Primary citation	Kim, J.,Yunn, N.O.,Park, M.,Kim, J.,Park, S.,Kim, Y.,Noh, J.,Ryu, S.H.,Cho, Y. Functional selectivity of insulin receptor revealed by aptamer-trapped receptor structures. Nat Commun, 13:6500-6500, 2022 Cited by PubMed: 36310231 DOI: 10.1038/s41467-022-34292-8 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (4.27 Å)

Structure validation