7YL2

Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor Y07004

7YL2 の概要

• エントリーDOI: 10.2210/pdb7yl2/pdb
• 分子名称: Bromodomain-containing protein 4, N-(1-ethyl-2-oxidanylidene-3H-indol-5-yl)cyclohexanesulfonamide, GLYCEROL, ... (5 entities in total)
• 機能のキーワード: brd4(1), bromodomain, inhibitor, antitumor protein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 17243.85

構造登録者

Huang, Y.,Wei, A.,Dong, R.,Xu, H.,Zhang, C.,Chen, Z.,Li, J.,Wu, X.,Zhang, Y.,Xu, Y. (登録日: 2022-07-25, 公開日: 2023-07-26, 最終更新日: 2024-05-29)

• 主引用文献: Huang, Y.,Wei, A.,Dong, R.,Xu, H.,Zhang, C.,Chen, Z.,Li, J.,Wu, X.,Zhang, Y.,Xu, Y.; Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor Y07004; To Be Published,

実験手法

X-RAY DIFFRACTION (1.62 Å)