7YF1

Structure of FABP at 1.7 Angstroms resolution.

7YF1 の概要

• エントリーDOI: 10.2210/pdb7yf1/pdb
• 分子名称: Fatty acid-binding protein, heart, PALMITIC ACID (3 entities in total)
• 機能のキーワード: fabp, lipid binding protein
• 由来する生物種: Mus musculus (house mouse)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 16067.26

構造登録者

Liu, Y.h.,Wang, L.l. (登録日: 2022-07-07, 公開日: 2022-09-21, 最終更新日: 2023-11-29)

主引用文献

Wang, L.,Zhang, H.,Lv, P.,Li, Y.,Teng, M.,Liu, Y.,Wu, D.
Structural Insights into Mouse H-FABP.
Life, 12:-, 2022

PubMed Abstract: Intracellular fatty acid-binding proteins are evolutionarily highly conserved proteins. The major functions and responsibilities of this family are the regulation of FA uptake and intracellular transport. The structure of the H-FABP ortholog from mouse () had not been revealed at the time this study was completed. Thus, further exploration of the structural properties of mouse H-FABP is expected to extend our knowledge of the model animal's molecular mechanism of H-FABP function. Here, we report the high-resolution crystal structure and the NMR characterization of mouse H-FABP. Our work discloses the unique structural features of mouse H-FABP, offering a structural basis for the further development of small-molecule inhibitors for H-FABP.

PubMed: 36143481
DOI: 10.3390/life12091445

実験手法

X-RAY DIFFRACTION (1.7 Å)