7YC3
Crystal structure of FGFR4 kinase domain with 10t
7YC3 の概要
エントリーDOI | 10.2210/pdb7yc3/pdb |
分子名称 | Fibroblast growth factor receptor 4, 6-bromanyl-~{N}-[5-cyano-4-(2-methoxyethylamino)pyridin-2-yl]-5-methanoyl-1-(2-morpholin-4-ylethyl)pyrrolo[3,2-b]pyridine-3-carboxamide, SULFATE ION, ... (5 entities in total) |
機能のキーワード | kinase, inhibitor, structural protein, transferase-transferase inhibitor complex, transferase, transferase-inhibitor complex, transferase/inhibitor |
由来する生物種 | Homo sapiens (human) |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 35815.94 |
構造登録者 | |
主引用文献 | Yang, F.,Chen, X.,Song, X.,Ortega, R.,Lin, X.,Deng, W.,Guo, J.,Tu, Z.,Patterson, A.V.,Smaill, J.B.,Chen, Y.,Lu, X. Design, Synthesis, and Biological Evaluation of 5-Formyl-pyrrolo[3,2- b ]pyridine-3-carboxamides as New Selective, Potent, and Reversible-Covalent FGFR4 Inhibitors. J.Med.Chem., 65:14809-14831, 2022 Cited by PubMed: 36278929DOI: 10.1021/acs.jmedchem.2c01319 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.987 Å) |
構造検証レポート
検証レポート(詳細版)をダウンロード