7Y9N

an engineered 5-helix bundle derived from SARS-CoV-2 S2 in complex with HR2P

7Y9N の概要

• エントリーDOI: 10.2210/pdb7y9n/pdb
• 分子名称: Spike protein S2',5HB-H2, SARS-coV-2 S2 subunit (3 entities in total)
• 機能のキーワード: 5hb, virus protein/inhibitor, virus protein-inhibitor complex
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2; 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 30361.70

構造登録者

Lu, G.W.,Lin, X.,Guo, L.Y.,Lin, S. (登録日: 2022-06-25, 公開日: 2022-08-17, 最終更新日: 2023-11-29)

• 主引用文献: Lin, X.,Guo, L.,Lin, S.,Chen, Z.,Yang, F.,Yang, J.,Wang, L.,Wen, A.,Duan, Y.,Zhang, X.,Dai, Y.,Yin, K.,Yuan, X.,Yu, C.,He, B.,Cao, Y.,Dong, H.,Li, J.,Zhao, Q.,Lu, G.; An engineered 5-helix bundle derived from SARS-CoV-2 S2 pre-binds sarbecoviral spike at both serological- and endosomal-pH to inhibit virus entry.; Emerg Microbes Infect, 11:1920-1935, 2022; PubMed: 35757908; DOI: 10.1080/22221751.2022.2095308

実験手法

X-RAY DIFFRACTION (1.885 Å)