7Y5T
CryoEM structure of PS1-containing gamma-secretase in complex with MRK-560
Summary for 7Y5T
Entry DOI | 10.2210/pdb7y5t/pdb |
EMDB information | 33624 |
Descriptor | Nicastrin, CHOLESTEROL, Presenilin-1, ... (10 entities in total) |
Functional Keywords | intramembrane protease, gamma-secretase, presenilin-1, membrane protein, membrane protein-hydrolase complex, membrane protein/hydrolase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 179871.32 |
Authors | |
Primary citation | Guo, X.,Wang, Y.,Zhou, J.,Jin, C.,Wang, J.,Jia, B.,Jing, D.,Yan, C.,Lei, J.,Zhou, R.,Shi, Y. Molecular basis for isoform-selective inhibition of presenilin-1 by MRK-560. Nat Commun, 13:6299-6299, 2022 Cited by PubMed: 36272978DOI: 10.1038/s41467-022-33817-5 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.9 Å) |
Structure validation
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