7Y4U

Crystal structure of cMET kinase domain bound by compound 9Y

Summary for 7Y4U

Entry DOI	10.2210/pdb7y4u/pdb
Descriptor	Hepatocyte growth factor receptor, ~{N}-methyl-4-[1-[2-[3-(1-methylpyrazol-4-yl)quinolin-6-yl]ethyl]-6-oxidanylidene-pyridazin-3-yl]-2-(trifluoromethyl)benzamide (3 entities in total)
Functional Keywords	transferase inhibitor, transferase, transferase-inhibitor complex, transferase/inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	35374.84
Authors	Qu, L.Z.,Chen, Y.H. (deposition date: 2022-06-16, release date: 2022-11-23, Last modification date: 2023-11-29)
Primary citation	Wang, C.,Li, J.,Qu, L.,Tang, X.,Song, X.,Yang, F.,Chen, X.,Lin, Q.,Lin, W.,Zhou, Y.,Tu, Z.,Chen, Y.,Zhang, Z.,Lu, X. Discovery of D6808, a Highly Selective and Potent Macrocyclic c-Met Inhibitor for Gastric Cancer Harboring MET Gene Alteration Treatment. J.Med.Chem., 65:15140-15164, 2022 Cited by PubMed: 36355693 DOI: 10.1021/acs.jmedchem.2c00981 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.26 Å)

Structure validation