7Y4S

Structure of human MG53 homo-dimer

7Y4S の概要

• エントリーDOI: 10.2210/pdb7y4s/pdb
• EMDBエントリー: 33606
• 分子名称: Tripartite motif-containing protein 72 (1 entity in total)
• 機能のキーワード: tripartite motif-containing protein 72, mg53, trim72, membrane repair, pry-spry domain, mitsugumin-53, structural protein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 105601.02

構造登録者

Chen, L.,Niu, Y. (登録日: 2022-06-16, 公開日: 2022-09-21, 最終更新日: 2024-07-03)

主引用文献

Niu, Y.,Chen, G.,Lv, F.,Xiao, R.P.,Hu, X.,Chen, L.
Cryo-EM structure of human MG53 homodimer.
Biochem.J., 479:1909-1916, 2022

PubMed Abstract: MG53 is a tripartite motif (TRIM) family E3 ligase and plays important biological functions. Here we present the cryo-EM structure of human MG53, showing that MG53 is a homodimer consisting of a 'body' and two 'wings'. Intermolecular interactions are mainly distributed in the 'body' which is relatively stable, while two 'wings' are more dynamic. The overall architecture of MG53 is distinct from those of TRIM20 and TRIM25, illustrating the broad structural diversity of this protein family.

PubMed: 36053137
DOI: 10.1042/BCJ20220385

実験手法

ELECTRON MICROSCOPY (3.5 Å)