7XZP

Formate-tetrahydrofolate ligase in complex with berberine

7XZP の概要

• エントリーDOI: 10.2210/pdb7xzp/pdb
• 分子名称: Formate--tetrahydrofolate ligase, BERBERINE, SULFATE ION, ... (5 entities in total)
• 機能のキーワード: formate tetrahydrofolate ligase, berberine, ligase
• 由来する生物種: Peptostreptococcus anaerobius
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 123740.01

構造登録者

Fang, C.L.,Zhang, Y. (登録日: 2022-06-03, 公開日: 2023-06-07, 最終更新日: 2023-12-20)

主引用文献

Yan, J.,Fang, C.,Yang, G.,Li, J.,Liu, Y.,Zhang, L.,Yang, P.,Fang, J.,Gu, Y.,Zhang, Y.,Jiang, W.
Identification of FtfL as a novel target of berberine in intestinal bacteria.
Bmc Biol., 21:280-280, 2023

PubMed Abstract: Berberine (BBR) is a commonly used anti-intestinal inflammation drug, and its anti-cancer activity has been found recently. BBR can intervene and control malignant colorectal cancer (CRC) through intestinal microbes, but the direct molecular target and related mechanism are unclear. This study aimed to identify the target of BBR and dissect related mechanisms against the occurrence and development of CRC from the perspective of intestinal microorganisms.

PubMed: 38049785
DOI: 10.1186/s12915-023-01778-w

実験手法

X-RAY DIFFRACTION (2.56 Å)