7XYH
Crystal structure of CK2a2 complexed with AG1112
Summary for 7XYH
Entry DOI | 10.2210/pdb7xyh/pdb |
Descriptor | Casein kinase II subunit alpha', 5-azanyl-3-[(~{Z})-1-cyano-2-(1~{H}-indol-3-yl)ethenyl]-1~{H}-pyrazole-4-carbonitrile, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | protein kinase, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 81613.34 |
Authors | Ikeda, A.,Kinoshita, T.,Tsuyuguchi, M. (deposition date: 2022-06-01, release date: 2023-01-18, Last modification date: 2023-11-29) |
Primary citation | Ikeda, A.,Tsuyuguchi, M.,Kitagawa, D.,Sawa, M.,Nakamura, S.,Nakanishi, I.,Kinoshita, T. Bivalent binding mode of an amino-pyrazole inhibitor indicates the potentials for CK2 alpha 1-selective inhibitors. Biochem.Biophys.Res.Commun., 630:30-35, 2022 Cited by PubMed: 36130444DOI: 10.1016/j.bbrc.2022.09.040 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.04 Å) |
Structure validation
Download full validation report