7XXI

Cryo-EM structure of the purinergic receptor P2Y12R in complex with 2MeSADP and Gi

7XXI の概要

• エントリーDOI: 10.2210/pdb7xxi/pdb
• EMDBエントリー: 33504
• 分子名称: P2Y purinoceptor 12, Guanine nucleotide-binding protein G(i) subunit alpha-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (5 entities in total)
• 機能のキーワード: g protein-coupled receptor, purinergic receptor, p2y12r, ligand binding, signal transduction, membrane protein
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 130748.18

構造登録者

Tan, Q.,Li, B.,Han, S.,Zhao, Q.,Wu, B. (登録日: 2022-05-30, 公開日: 2023-06-07, 最終更新日: 2025-07-02)

• 主引用文献: Li, B.,Han, S.,Wang, M.,Yu, Y.,Ma, L.,Chu, X.,Tan, Q.,Zhao, Q.,Wu, B.; Structural insights into signal transduction of the purinergic receptors P2Y1R and P2Y12R.; Protein Cell, 14:382-386, 2023; PubMed: 37155313; DOI: 10.1093/procel/pwac025

実験手法

ELECTRON MICROSCOPY (3 Å)