7XW6

TSHR-Gs-M22 antibody-ML109 complex

Summary for 7XW6

• Entry DOI: 10.2210/pdb7xw6/pdb
• EMDB information: 33492
• Descriptor: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, PALMITIC ACID, ~{N}-[4-[[2-methoxy-5-[(2~{S})-5-oxidanyl-4-oxidanylidene-3-(phenylmethyl)-1,2-dihydroquinazolin-2-yl]phenyl]methoxy]phenyl]ethanamide, ... (11 entities in total)
• Functional Keywords: thyroid-stimulating hormone, thyroid-stimulating hormone receptor, ths, thsr, gpcr, gs, ml-109, m22, scfv, membrane protein
• Biological source: Homo sapiens; More
• Total number of polymer chains: 7
• Total formula weight: 204812.04

Authors

Duan, J.,Xu, P.,Luan, X.,Ji, Y.,Yuan, Q.,He, X.,Ye, J.,Cheng, X.,Jiang, H.,Zhang, S.,Jiang, Y.,Xu, H.E. (deposition date: 2022-05-26, release date: 2022-08-17, Last modification date: 2022-10-05)

• Primary citation: Duan, J.,Xu, P.,Luan, X.,Ji, Y.,He, X.,Song, N.,Yuan, Q.,Jin, Y.,Cheng, X.,Jiang, H.,Zheng, J.,Zhang, S.,Jiang, Y.,Xu, H.E.; Hormone- and antibody-mediated activation of the thyrotropin receptor.; Nature, 609:854-859, 2022; PubMed: 35940204; DOI: 10.1038/s41586-022-05173-3

Experimental method

ELECTRON MICROSCOPY (2.78 Å)