7XUD

Structure of G9a in complex with compound 26a

7XUD の概要

• エントリーDOI: 10.2210/pdb7xud/pdb
• 分子名称: Histone-lysine N-methyltransferase EHMT2, ZINC ION, CHLORIDE ION, ... (8 entities in total)
• 機能のキーワード: histone lysine methyltransferase, inhibitor, protein-inhibitor complex, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 67682.76

構造登録者

Niwa, H.,Shirai, F.,Sato, S.,Nishigaya, Y.,Umehara, T. (登録日: 2022-05-18, 公開日: 2023-03-29, 最終更新日: 2023-11-29)

• 主引用文献: Nishigaya, Y.,Takase, S.,Sumiya, T.,Kikuzato, K.,Sato, T.,Niwa, H.,Sato, S.,Nakata, A.,Sonoda, T.,Hashimoto, N.,Namie, R.,Honma, T.,Umehara, T.,Shirouzu, M.,Koyama, H.,Yoshida, M.,Ito, A.,Shirai, F.; Discovery of Novel Substrate-Competitive Lysine Methyltransferase G9a Inhibitors as Anticancer Agents.; J.Med.Chem., 66:4059-4085, 2023; PubMed: 36882960; DOI: 10.1021/acs.jmedchem.2c02059

実験手法

X-RAY DIFFRACTION (1.45 Å)