7XTQ

Cryo-EM structure of the R399-bound GPBAR-Gs complex

7XTQ の概要

• エントリーDOI: 10.2210/pdb7xtq/pdb
• EMDBエントリー: 33452
• 分子名称: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
• 機能のキーワード: gpcr, gpbar, complex, bile acid, membrane protein
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 141107.84

構造登録者

Ma, L.,Yang, F.,Wu, X.,Mao, C.,Sun, J.,Yu, X.,Zhang, Y.,Zhang, P. (登録日: 2022-05-17, 公開日: 2022-07-06, 最終更新日: 2022-08-03)

• 主引用文献: Ma, L.,Yang, F.,Wu, X.,Mao, C.,Guo, L.,Miao, T.,Zang, S.K.,Jiang, X.,Shen, D.D.,Wei, T.,Zhou, H.,Wei, Q.,Li, S.,Shu, Q.,Feng, S.,Jiang, C.,Chu, B.,Du, L.,Sun, J.P.,Yu, X.,Zhang, Y.,Zhang, P.; Structural basis and molecular mechanism of biased GPBAR signaling in regulating NSCLC cell growth via YAP activity.; Proc.Natl.Acad.Sci.USA, 119:e2117054119-e2117054119, 2022; PubMed: 35858343; DOI: 10.1073/pnas.2117054119

実験手法

ELECTRON MICROSCOPY (3.2 Å)