7XTC

Serotonin 7 (5-HT7) receptor-Gs-Nb35 complex

7XTC の概要

• エントリーDOI: 10.2210/pdb7xtc/pdb
• EMDBエントリー: 33446
• 分子名称: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (7 entities in total)
• 機能のキーワード: gpcr, serotonin receptor, 5-ht, 5-ht7 receptor, signaling complex, cryo-em structure, ligand selectivity, g protein selectivity, structure-function relationships, membrane protein
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 171771.18

構造登録者

Huang, S.,Xu, P.,Shen, D.D.,Simon, I.A.,Mao, C.,Tan, Y.,Zhang, H.,Harpsoe, K.,Li, H.,Zhang, Y.,You, C.,Yu, X.,Jiang, Y.,Zhang, Y.,Gloriam, D.E.,Xu, H.E. (登録日: 2022-05-16, 公開日: 2022-07-27, 最終更新日: 2022-08-03)

• 主引用文献: Huang, S.,Xu, P.,Shen, D.D.,Simon, I.A.,Mao, C.,Tan, Y.,Zhang, H.,Harpsoe, K.,Li, H.,Zhang, Y.,You, C.,Yu, X.,Jiang, Y.,Zhang, Y.,Gloriam, D.E.,Xu, H.E.; GPCRs steer G i and G s selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors.; Mol.Cell, 82:2681-2695.e6, 2022; PubMed: 35714614; DOI: 10.1016/j.molcel.2022.05.031

実験手法

ELECTRON MICROSCOPY (3.2 Å)