7XNE

Crystal structure of CBP bromodomain liganded with Y08284

7XNE の概要

• エントリーDOI: 10.2210/pdb7xne/pdb
• 分子名称: CREB-binding protein, N-[3-(1-cyclopropylpyrazol-4-yl)-2-fluoranyl-5-[(1S)-1-oxidanylethyl]phenyl]-3-ethanoyl-7-methoxy-indolizine-1-carboxamide, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: histone acetyltransferase, protein binding
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 32827.69

構造登録者

Xiang, Q.,Wang, C.,Wu, T.,Zhang, C.,Hu, Q.,Luo, G.,Hu, J.,Zhuang, X.,Zou, L.,Shen, H.,Wu, X.,Zhang, Y.,Kong, X.,Xu, Y. (登録日: 2022-04-28, 公開日: 2022-07-06, 最終更新日: 2023-11-29)

• 主引用文献: Xiang, Q.,Wang, C.,Wu, T.,Zhang, C.,Hu, Q.,Luo, G.,Hu, J.,Zhuang, X.,Zou, L.,Shen, H.,Wu, X.,Zhang, Y.,Kong, X.,Liu, J.,Xu, Y.; Design, Synthesis, and Biological Evaluation of 1-(Indolizin-3-yl)ethan-1-ones as CBP Bromodomain Inhibitors for the Treatment of Prostate Cancer.; J.Med.Chem., 65:785-810, 2022; PubMed: 34962793; DOI: 10.1021/acs.jmedchem.1c01864

実験手法

X-RAY DIFFRACTION (2.17 Å)