7XMK
Crystal structure of human RIPK1 kinase domain in complex with compound SKLB923
Summary for 7XMK
Entry DOI | 10.2210/pdb7xmk/pdb |
Descriptor | Receptor-interacting serine/threonine-protein kinase 1, IODIDE ION, 5-[2-(cyclopropylcarbonylamino)-[1,2,4]triazolo[1,5-a]pyridin-7-yl]-N-[(1S)-1-(3-fluorophenyl)ethyl]-1-methyl-indole-3-carboxamide, ... (4 entities in total) |
Functional Keywords | ripk1, kinase, complex, inhibitor, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 68184.34 |
Authors | |
Primary citation | Zhang, L.,Li, Y.,Tian, C.,Yang, R.,Wang, Y.,Xu, H.,Zhu, Q.,Chen, S.,Li, L.,Yang, S. From Hit to Lead: Structure-Based Optimization of Novel Selective Inhibitors of Receptor-Interacting Protein Kinase 1 (RIPK1) for the Treatment of Inflammatory Diseases. J.Med.Chem., 67:754-773, 2024 Cited by PubMed: 38159286DOI: 10.1021/acs.jmedchem.3c02102 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.376 Å) |
Structure validation
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