7XMK

Crystal structure of human RIPK1 kinase domain in complex with compound SKLB923

7XMK の概要

• エントリーDOI: 10.2210/pdb7xmk/pdb
• 分子名称: Receptor-interacting serine/threonine-protein kinase 1, IODIDE ION, 5-[2-(cyclopropylcarbonylamino)-[1,2,4]triazolo[1,5-a]pyridin-7-yl]-N-[(1S)-1-(3-fluorophenyl)ethyl]-1-methyl-indole-3-carboxamide, ... (4 entities in total)
• 機能のキーワード: ripk1, kinase, complex, inhibitor, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 68184.34

構造登録者

Zhang, L.,Wang, Y.,Li, Y.,Yang, S. (登録日: 2022-04-26, 公開日: 2023-04-26, 最終更新日: 2024-05-15)

• 主引用文献: Zhang, L.,Li, Y.,Tian, C.,Yang, R.,Wang, Y.,Xu, H.,Zhu, Q.,Chen, S.,Li, L.,Yang, S.; From Hit to Lead: Structure-Based Optimization of Novel Selective Inhibitors of Receptor-Interacting Protein Kinase 1 (RIPK1) for the Treatment of Inflammatory Diseases.; J.Med.Chem., 67:754-773, 2024; PubMed: 38159286; DOI: 10.1021/acs.jmedchem.3c02102

実験手法

X-RAY DIFFRACTION (2.376 Å)