7XHY
Crystal structure of MerTK Kinase domain with BMS794833
Summary for 7XHY
Entry DOI | 10.2210/pdb7xhy/pdb |
Descriptor | Tyrosine-protein kinase Mer, ~{N}-[4-(2-azanyl-3-chloranyl-pyridin-4-yl)oxy-3-fluoranyl-phenyl]-5-(4-fluorophenyl)-4-oxidanylidene-1~{H}-pyridine-3-carboxamide, CHLORIDE ION, ... (5 entities in total) |
Functional Keywords | atp competitive inhibitor mertk-bms794833 complex, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 35070.54 |
Authors | |
Primary citation | Bae, S.H.,Kim, J.H.,Park, T.H.,Lee, K.,Lee, B.I.,Jang, H. BMS794833 inhibits macrophage efferocytosis by directly binding to MERTK and inhibiting its activity. Exp.Mol.Med., 54:1450-1460, 2022 Cited by PubMed: 36056187DOI: 10.1038/s12276-022-00840-x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.16 Å) |
Structure validation
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