7XH2

Dihydrofolate Reductase-like Protein SacH in safracin biosynthesis

Summary for 7XH2

Entry DOI	10.2210/pdb7xh2/pdb
Descriptor	Uncharacterized protein sfcH, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE (3 entities in total)
Functional Keywords	reductase, safracin biosynthesis, self-resistance., oxidoreductase
Biological source	Pseudomonas fluorescens
Total number of polymer chains	1
Total formula weight	22764.26
Authors	Ma, X.,Shao, N.,Ma, M.,Tang, G. (deposition date: 2022-04-07, release date: 2023-02-08, Last modification date: 2023-11-29)
Primary citation	Shao, N.,Ma, X.,Zhang, Y.Y.,Yang, D.,Ma, M.,Tang, G.L. Dihydrofolate reductase-like protein inactivates hemiaminal pharmacophore for self-resistance in safracin biosynthesis. Acta Pharm Sin B, 13:1318-1325, 2023 Cited by PubMed: 36970210 DOI: 10.1016/j.apsb.2022.10.005 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation