7XDG

Cryo-EM structures of human mitochondrial NAD(P)+-dependent malic enzyme in a ternary complex with NAD+ and allosteric inhibitor MDSA

Summary for 7XDG

• Entry DOI: 10.2210/pdb7xdg/pdb
• EMDB information: 33147
• Descriptor: NAD-dependent malic enzyme, mitochondrial, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 5-[(3-carboxy-4-oxidanyl-phenyl)methyl]-2-oxidanyl-benzoic acid (3 entities in total)
• Functional Keywords: human mitochondrial nad(p)+-dependent malic enzyme (me2), inhibitor, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 268546.14

Authors

Wang, C.H.,Hsieh, J.T.,Ho, M.C.,Hung, H.C. (deposition date: 2022-03-27, release date: 2023-03-29, Last modification date: 2024-06-26)

• Primary citation: Hsieh, J.Y.,Chen, K.C.,Wang, C.H.,Liu, G.Y.,Ye, J.A.,Chou, Y.T.,Lin, Y.C.,Lyu, C.J.,Chang, R.Y.,Liu, Y.L.,Li, Y.H.,Lee, M.R.,Ho, M.C.,Hung, H.C.; Suppression of the human malic enzyme 2 modifies energy metabolism and inhibits cellular respiration; Commun Biol, 6:548-, 2023; DOI: 10.1038/s42003-023-04930-y

Experimental method

ELECTRON MICROSCOPY (2.84 Å)