7XAX

Crystal structure of SARS coronavirus main protease in complex with Baicalei

7XAX の概要

• エントリーDOI: 10.2210/pdb7xax/pdb
• 分子名称: 3C-like proteinase nsp5, 5,6,7-trihydroxy-2-phenyl-4H-chromen-4-one (3 entities in total)
• 機能のキーワード: sars, viral protein
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 68023.51

構造登録者

Zhou, X.L.,Li, J.,Zhang, J. (登録日: 2022-03-19, 公開日: 2023-03-22, 最終更新日: 2024-10-02)

主引用文献

Feng, J.,Li, D.,Zhang, J.,Yin, X.,Li, J.
Crystal structure of SARS-CoV 3C-like protease with baicalein.
Biochem.Biophys.Res.Commun., 611:190-194, 2022

PubMed Abstract: The 3C-like protease (M, 3CL) plays a key role in the replication process in coronaviruses (CoVs). The M is an essential enzyme mediates CoVs replication and is a promising target for development of antiviral drugs. Until now, baicalein has been shown the specific activity for SARS-CoV M in vitro experiments. In this study, we resolved the SARS-CoV M with baicalein by X-ray diffraction at 2.25 Å (PDB code 7XAX), which provided a structural basis for the research and development of baicalein as an anti-CoVs drug.

PubMed: 35490659
DOI: 10.1016/j.bbrc.2022.04.086

実験手法

X-RAY DIFFRACTION (2.25 Å)