7XAF

The crystal structure of TrkA kinase in complex with 4^6,14-dimethyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-10-oxo-5-oxa-11,14-diaza-1(3,6)-imidazo[1,2-b]pyridazina-4(1,3)-benzenacyclo- tetradecaphan-2-yne-45-carboxamide

Summary for 7XAF

• Entry DOI: 10.2210/pdb7xaf/pdb
• Descriptor: High affinity nerve growth factor receptor, 4^6,14-dimethyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-10-oxo-5-oxa-11,14-diaza-1(3,6)-imidazo[1,2-b]pyridazina-4(1,3)-benzenacyclo-tetradecaphan-2-yne-45-carboxamide (2 entities in total)
• Functional Keywords: trka, transferase inhibitor, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 34577.83

Authors

Zhang, Z.M.,Wang, Y.J. (deposition date: 2022-03-17, release date: 2022-06-01, Last modification date: 2023-11-29)

• Primary citation: Wang, Z.,Wang, J.,Wang, Y.,Xiang, S.,Song, X.,Tu, Z.,Zhou, Y.,Zhang, Z.M.,Zhang, Z.,Ding, K.,Lu, X.; Discovery of the First Highly Selective and Broadly Effective Macrocycle-Based Type II TRK Inhibitors that Overcome Clinically Acquired Resistance.; J.Med.Chem., 65:6325-6337, 2022; PubMed: 35426680; DOI: 10.1021/acs.jmedchem.2c00308

Experimental method

X-RAY DIFFRACTION (3.00118200625 Å)