7XAF
The crystal structure of TrkA kinase in complex with 4^6,14-dimethyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-10-oxo-5-oxa-11,14-diaza-1(3,6)-imidazo[1,2-b]pyridazina-4(1,3)-benzenacyclo- tetradecaphan-2-yne-45-carboxamide
Summary for 7XAF
Entry DOI | 10.2210/pdb7xaf/pdb |
Descriptor | High affinity nerve growth factor receptor, 4^6,14-dimethyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-10-oxo-5-oxa-11,14-diaza-1(3,6)-imidazo[1,2-b]pyridazina-4(1,3)-benzenacyclo-tetradecaphan-2-yne-45-carboxamide (2 entities in total) |
Functional Keywords | trka, transferase inhibitor, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 34577.83 |
Authors | Zhang, Z.M.,Wang, Y.J. (deposition date: 2022-03-17, release date: 2022-06-01, Last modification date: 2023-11-29) |
Primary citation | Wang, Z.,Wang, J.,Wang, Y.,Xiang, S.,Song, X.,Tu, Z.,Zhou, Y.,Zhang, Z.M.,Zhang, Z.,Ding, K.,Lu, X. Discovery of the First Highly Selective and Broadly Effective Macrocycle-Based Type II TRK Inhibitors that Overcome Clinically Acquired Resistance. J.Med.Chem., 65:6325-6337, 2022 Cited by PubMed: 35426680DOI: 10.1021/acs.jmedchem.2c00308 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.00118200625 Å) |
Structure validation
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