7XAB
Crystal structure of PDE4D catalytic domain complexed with compound 22d
Summary for 7XAB
Entry DOI | 10.2210/pdb7xab/pdb |
Descriptor | Isoform 3 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | pde4 inhibitor, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 117005.73 |
Authors | Huang, Y.-Y.,He, X.,Luo, H.-B. (deposition date: 2022-03-17, release date: 2023-02-22, Last modification date: 2023-11-29) |
Primary citation | Liu, H.,Wang, Q.,Huang, Y.,Deng, J.,Xie, X.,Zhu, J.,Yuan, Y.,He, Y.M.,Huang, Y.Y.,Luo, H.B.,He, X. Discovery of novel PDE4 inhibitors targeting the M-pocket from natural mangostanin with improved safety for the treatment of Inflammatory Bowel Diseases. Eur.J.Med.Chem., 242:114631-114631, 2022 Cited by PubMed: 35985255DOI: 10.1016/j.ejmech.2022.114631 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.00067450802 Å) |
Structure validation
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