7X88

Crystal structure of ENL YEATS domain T2 mutant in complex with histone H3 acetylation at K27

Summary for 7X88

• Entry DOI: 10.2210/pdb7x88/pdb
• Descriptor: Protein ENL, Histone H3K27ac(24-27) peptide, CITRIC ACID, ... (4 entities in total)
• Functional Keywords: yeats domain, complex, histone, transcription, gene regulation
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 19006.77

Authors

Li, Y.Y.,Li, H.T. (deposition date: 2022-03-11, release date: 2023-01-18, Last modification date: 2023-11-29)

• Primary citation: Song, L.,Yao, X.,Li, H.,Peng, B.,Boka, A.P.,Liu, Y.,Chen, G.,Liu, Z.,Mathias, K.M.,Xia, L.,Li, Q.,Mir, M.,Li, Y.,Li, H.,Wan, L.; Hotspot mutations in the structured ENL YEATS domain link aberrant transcriptional condensates and cancer.; Mol.Cell, 82:4080-4098.e12, 2022; PubMed: 36272410; DOI: 10.1016/j.molcel.2022.09.034

Experimental method

X-RAY DIFFRACTION (2.25 Å)