7X1R

Cryo-EM structure of human thioredoxin reductase bound by Au

Summary for 7X1R

• Entry DOI: 10.2210/pdb7x1r/pdb
• EMDB information: 32947
• Descriptor: Thioredoxin reductase 1, cytoplasmic, FLAVIN-ADENINE DINUCLEOTIDE, GOLD ION (3 entities in total)
• Functional Keywords: protein-metal complex, homodimeric, oxidoreductase, redox-active center, fad
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 114198.71

Authors

He, Z.S.,Cao, P.,Cao, S.H.,He, B.,Jiang, H.D.,Gong, Y.,Gao, X.Y. (deposition date: 2022-02-24, release date: 2022-12-14, Last modification date: 2024-10-30)

• Primary citation: Du, Z.,He, Z.,Fan, J.,Huo, Y.,He, B.,Wang, Y.,Sun, Q.,Niu, W.,Zhao, W.,Zhao, L.,Cao, P.,Cao, K.,Xia, D.,Yuan, Q.,Liang, X.J.,Jiang, H.,Gong, Y.,Gao, X.; Au4 cluster inhibits human thioredoxin reductase activity via specifically binding of Au to Cys189; Nano Today, 47:101686-, 2022; DOI: 10.1016/j.nantod.2022.101686

Experimental method

ELECTRON MICROSCOPY (3.9 Å)