7X12
Crystal structure of ME1 in complex with NADPH
Summary for 7X12
Entry DOI | 10.2210/pdb7x12/pdb |
Descriptor | NADP-dependent malic enzyme, MANGANESE (II) ION, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total) |
Functional Keywords | malic enzyme, complex, oxidoreductase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 260094.97 |
Authors | Amano, Y. (deposition date: 2022-02-22, release date: 2022-07-20, Last modification date: 2023-11-29) |
Primary citation | Yoshida, T.,Kawabe, T.,Cantley, L.C.,Lyssiotis, C.A. Discovery and Characterization of a Novel Allosteric Small-Molecule Inhibitor of NADP + -Dependent Malic Enzyme 1. Biochemistry, 61:1548-1553, 2022 Cited by PubMed: 35819845DOI: 10.1021/acs.biochem.2c00123 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.07 Å) |
Structure validation
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